- Title
- Steroids from an Australian sponge Psammoclema sp.
- Creator
- Holland, Ian P.; McCluskey, Adam; Sakoff, Jennette A.; Gilbert, Jayne; Chau, Ngoc; Robinson, Phillip J.; Motti, Cherie A; Wright, Anthony D.; Van Altena, Ian A.
- Relation
- Journal of Natural Products Vol. 72, Issue 1, p. 102-106
- Publisher Link
- http://dx.doi.org/10.1021/np800688f
- Publisher
- American Chemical Society
- Resource Type
- journal article
- Date
- 2009
- Description
- Investigation of an extract of the Australian marine sponge Psammoclema sp. for dynamin I inhibitory activity led to the isolation of four new trihydroxysterols (1−4) related to aragusterol G. These compounds were largely identified by 1D and 2D NMR spectroscopic methods. While 1 was found to be inactive in the dynamin bioassay, bioassays did reveal that compounds 1−4 inhibited the growth of colorectal, breast, ovarian, and prostate cancer cell lines (GI₅₀ 5−27 μM). The additional insight that these new compounds give to previous SAR studies is discussed briefly.
- Subject
- Psammoclema sp.; steroids; cancer; SAR studies
- Identifier
- uon:7404
- Identifier
- http://hdl.handle.net/1959.13/807409
- Identifier
- ISSN:0163-3864
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